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KMID : 0379520150310010033
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한국독성학회지
2015 Volume.31 No. 1 p.33 ~ p.40
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Improved Therapeutic Profiles of PLA2-Free Bee Venom Prepared by Ultrafiltration Method
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Lee Hyun-kyoung
Pyo Min-Jung
Bae Seong-Kyeong
Heo Yun-wi
Kim Choul-Goo
Kang Chang-Keun
Kim Eui-Kyung
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Abstract
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Bee venom (BV) has long been used in traditional Eastern and Western medicine for chronic inflammation, pain and skin therapy. Human exposure to BV, however, often causes unwanted adverse effects and is even fatal in some cases. Phospholipase A2 (PLA2) of BV is now suspected to play a key role in these adverse effects. We investigated the potential use of PLA2-free bee venom (PBV) as a replacement for BV in cosmetic products. PBV prepared by molecular weight cut-off ultrafiltration exhibits a superior profile in comparison with regular BV, by inhibiting elastase activity and suppressing the induction of nitric oxide (NO) and metalloproteinase-9 (MMP-9), while retaining the effects of cell proliferation and protection against ultraviolet B (UVB)-induced damage in human dermal fibroblast cells. PBV thus appears to be more promising than BV as a cosmetic ingredient with a reduced potential for adverse reactions in the recipient.
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KEYWORD
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Bee venom, Phospholipase A2 free, Ultrafiltration, Human dermal fibroblast, Ultraviolet B, Cosmetic product
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